Show host Savannah Guthrie has released a statement amid her 84-year-old mother’s disappearance, with investigators saying she is believed to have been abducted from her Arizona home while she was sleeping.

Nancy Guthrie was last seen in the Catalina Foothills area on Saturday night, according to the Pima County Sheriff’s Department. Her family reported her missing on Sunday around noon local time, authorities said.

Investigators do not believe Nancy Guthrie left her home willingly and that she was abducted in her sleep early Sunday morning, the Pima County Sheriff’s Department told ABC News.

In a post to Instagram on Monday night, Savannah Guthrie asked her followers for prayers amid the investigation.

“Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant. raise your prayers with us and believe with us that she will be lifted by them in this very moment,” the talk show host wrote, alongside a prayer.

“Bring her home,” she concluded her message.

Pima County Sheriff Chris Nanos said investigators processed Nancy Guthrie’s home on Sunday and “saw some things at the home that were concerning to us,” and that it is considered a crime scene.

“She did not leave on her own, we know that,” Nanos said during a press briefing on Monday.

Nancy Guthrie is described as having some physical ailments and limited mobility, but does not have cognitive issues, her family said, according to the sheriff.She takes medication that if she doesn’t have in 24 hours, “it could be fatal,” Nanos said Monday.

“So we make a plea to anyone that knows anything about this, who has seen something, heard something, to contact us, call 911,” he said, urging residents to check any home security cameras.

The search and rescue effort for Nancy Guthrie, which was conducted late into Sunday night “to no avail,” has ended for the time being, Nanos said.

“Right now, we don’t see this as a search mission, as much as we do a crime scene,” he said.

The FBI said it is assisting in the investigation.

There’s no indication at this time that the public is in danger, authorities said.

Authorities said they are reviewing the home’s security cameras and have Nancy Guthrie’s cellphone.

Sources briefed on the probe told ABC News that investigators are focusing on Nancy Guthrie’s electronic devices to see if there is data that could point to an assailant or a specific time when the abduction would have occurred.

Investigators are also paying careful attention to the condition of the home and whether things were moved or left out of place, which could suggest that someone with greater strength or agility would have been in the home and when, sources said.

Nancy Guthrie was last seen Saturday night by family members, Nanos said. Her children brought her home, where she lives alone, around 9:45 p.m. local time, according to Nanos. The following morning, her family got a call from their mother’s church saying she wasn’t there, he said.

“The family went to the house. I’m thinking they spent some time looking for her themselves before they called us,” he said.

Investigators found “circumstances on scene that we believe are suspicious in nature,” Sgt. David Stivers from the sheriff’s department’s homicide team, said during the press briefing Monday, though he did not go into further detail.

It is unclear if this was targeted, Nanos said. When asked whether Savannah Guthrie has received any threats, the sheriff said his department has been in touch with her security team and is unaware of any such threats at the moment.

“We’re not going to dismiss any angles for sure, but right now, immediately, we don’t know of anything like that,” Nanos said.

An NBCUniversal spokesperson confirmed early on Monday that Nancy Guthrie is missing and said the family is “working closely with local law enforcement.”

“On behalf of our family, I want to thank everyone for the thoughts, prayers and messages of support,” Savannah Guthrie said in a statement read by Craig Melvin on the “Today” show on Monday. “Right now, our focus remains on the safe return of our dear mom.”

“We thank law enforcement for their hard work on this case and encourage anyone with information to contact the Pima County Sheriff’s Department at 520-351-4900,” the statement continued.

ABC News’ Cecilie Larcher contributed to this report.